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Molecule Parameter List for CaMKII-thr286*-CaM

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CaMKII-thr286*-CaM participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	2	0	1	2	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_CaMKII_ strong_coupling	64	Network	Shared_Object_AMPAR_CaMKII_strong_coupling,  CaMKII,  CaM,   PP1,  AMPAR_memb,  PP2B,   PKA,  AC,  PP1_PSD,   AMPAR
This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

CaMKII-thr286*-CaM acting as a Molecule in  AMPAR_CaMKII_strong_coupling Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII-thr286*-CaM	AMPAR_CaMKII_ strong_coupling Accession No. : 64	CaMKII Pathway No. : 272	0	0.09	No
From Hanson and Schulman, the thr286 is responsible for autonomous activation of CaMKII.

CaMKII-thr286*-CaM acting as a Summed Molecule in  AMPAR_CaMKII_strong_coupling Network

	Accession Nane	Pathway Name	Target	Input
1	AMPAR_CaMKII_ strong_coupling Accession No. : 64	CaMKII Pathway No. : 272	tot_CaM_CaMKII	CaMKII-CaM CaMKII-thr286*-C aM
2	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	tot_CaMKII_cyt	CaMKII-CaM CaMKII-thr286*-C aM CaMKII-thr286 CaMKII*** CaMK-thr305 CaMKII basal_CaMKII_ cyt

CaMKII-thr286*-CaM acting as a Substrate for an Enzyme in  AMPAR_CaMKII_strong_coupling Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PP1-active  / Deph-thr286	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	5.09905	2.5	4	explicit E-S complex	Substrate CaMKII-thr286*-C aM Product CaMKII-CaM

CaMKII-thr286*-CaM acting as a Product of an Enzyme in  AMPAR_CaMKII_strong_coupling Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot_CaM_CaMKII  / CaM_act_286	AMPAR_CaMKII_ strong_coupling Accession No. : 64	CaMKII Pathway No. : 272	226.998	0.5	4	explicit E-S complex	Substrate CaMKII-CaM Product CaMKII-thr286*-C aM
2	tot_autonomous_ CaMKII  / auton_286	AMPAR_CaMKII_ strong_coupling Accession No. : 64	CaMKII Pathway No. : 272	349.987	0.5	4	explicit E-S complex	Substrate CaMKII-CaM Product CaMKII-thr286*-C aM

CaMKII-thr286*-CaM acting as a Substrate in a reaction in  AMPAR_CaMKII_strong_coupling Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
transloc_2	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0 (#^-1 s^-1)	0 (s^-1)	Not applicable**	-	Substrate CaMKII-thr286*-C aM NMDAR Product CaMKII-thr286-Ca M-PSD
Same as for transloc_1

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

CaMKII-thr286*-CaM acting as a Product in a reaction in  AMPAR_CaMKII_strong_coupling Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CaMK-thr286-bind -CaM	AMPAR_CaMKII_ strong_coupling Accession No. : 64	CaMKII Pathway No. : 272	1000.19 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0001(uM)	-	Substrate CaM-Ca4 CaMKII-thr286 Product CaMKII-thr286*-C aM
Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3