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Molecule Parameter List for neurogranin-CaM

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
neurogranin-CaM participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    strong_coupling
    		• 64Network
    Shared_Object_AMPAR_CaMKII_strong_coupling,  CaMKII,  CaM,  
    PP1,  AMPAR_memb,  PP2B,  
    PKA,  AC,  PP1_PSD,  
    AMPAR 
    This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

    neurogranin-CaM acting as a Molecule in      AMPAR_CaMKII_strong_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    neurogranin-CaM
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
    		• CaM
    Pathway No. : 273    		00.09No

    neurogranin-CaM acting as a Substrate for an Enzyme in      AMPAR_CaMKII_strong_coupling Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PKC-active  /
  • PKC-phosph-ng-Ca
    M
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• 28.59560.354explicit E-S complexSubstrate
    neurogranin-CaM

    Product
    CaM
    neurogranin*
    Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993

    neurogranin-CaM acting as a Product in a reaction in      AMPAR_CaMKII_strong_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • neurogranin-bind
    -CaM
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
    		• CaM
    Pathway No. : 273    		0.3
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 3.3333(uM)-Substrate
    CaM
    neurogranin

    Product
    neurogranin-CaM
    Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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