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Molecule Parameter List for neurogranin*_PSD | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | AMPAR_CaMKII_
strong_coupling | 64 | Network |
Shared_Object_AMPAR_CaMKII_strong_coupling, CaMKII, CaM,
PP1, AMPAR_memb, PP2B,
PKA, AC, PP1_PSD,
AMPAR | | This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on. |
neurogranin*_PSD acting as a Molecule in AMPAR_CaMKII_strong_coupling Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | neurogranin*_PSD | AMPAR_CaMKII_
strong_coupling
Accession No. : 64 | CaM
Pathway No. : 273 | 0 | 0.01 | No | | The phosph form does not bind CaM (Huang et al ABB 305:2 570-580 1993) |
neurogranin*_PSD acting as a Substrate for an Enzyme in AMPAR_CaMKII_strong_coupling Network
neurogranin*_PSD acting as a Product of an Enzyme in AMPAR_CaMKII_strong_coupling Network
neurogranin*_PSD acting as a Substrate in a reaction in AMPAR_CaMKII_strong_coupling Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
dephosph-neurogr
anin_
PSD | AMPAR_CaMKII_
strong_coupling
Accession No. : 64 | CaM
Pathway No. : 273 | 0.005
(s^-1) | 0
(s^-1) | - | - | Substrate
neurogranin*_
PSD
Product
neurogranin_PSD
| | This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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