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Molecule Parameter List for CaM-Ca3

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaM-Ca3 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    strong_coupling
    		• 64Network
    Shared_Object_AMPAR_CaMKII_strong_coupling,  CaMKII,  CaM,  
    PP1,  AMPAR_memb,  PP2B,  
    PKA,  AC,  PP1_PSD,  
    AMPAR 
    This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

    CaM-Ca3 acting as a Molecule in      AMPAR_CaMKII_strong_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    CaM-Ca3
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• 00.09No

    CaM-Ca3 acting as a Substrate in a reaction in      AMPAR_CaMKII_strong_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    CaM-Ca3-bind-Ca
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• 0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5054(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
    Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10

    CaM-Ca3 acting as a Product in a reaction in      AMPAR_CaMKII_strong_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • CaM-TR2-Ca2-bind
    -Ca
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
    		• CaM
    Pathway No. : 273    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
    K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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