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Molecule Parameter List for PP2A

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PP2A participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1040000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    strong_coupling
    		• 64Network
    Shared_Object_AMPAR_CaMKII_strong_coupling,  CaMKII,  CaM,  
    PP1,  AMPAR_memb,  PP2B,  
    PKA,  AC,  PP1_PSD,  
    AMPAR 
    This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

    PP2A acting as a Molecule in      AMPAR_CaMKII_strong_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    PP2A
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• 0.11110.09No

    PP2A acting as an Enzyme in      AMPAR_CaMKII_strong_coupling Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PP2A /
  • PP2A-dephosph-I1
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• 15.999924.1667explicit E-S complexSubstrate
    I1*

    Product
    I1
        PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
    2PP2A /
  • PP2A-dephosph-PP
    1-I*
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• 15.999924.1667explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1
        k1 changed from 3.3e-6 to 6.6e-6
    3PP2A /

  • PP2A-dephosph-I1
    _
    PSD
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• 15.999924.1667explicit E-S complexSubstrate
    I1*

    Product
    I1
        PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
    4PP2A /

  • PP2A-dephosph-PP
    1-I*_
    PSD
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• 15.999924.1667explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1
        k1 changed from 3.3e-6 to 6.6e-6


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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