Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

Search in:

ALL Accession Pathway Molecule Enzyme Reaction Connected to

Search for

Match

Anything Exact Word Starting With

By

Name Notes Model

Molecule Parameter List for PP2A

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

PP2A participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	4	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_CaMKII_ strong_coupling	64	Network	Shared_Object_AMPAR_CaMKII_strong_coupling,  CaMKII,  CaM,   PP1,  AMPAR_memb,  PP2B,   PKA,  AC,  PP1_PSD,   AMPAR
This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

PP2A acting as a Molecule in  AMPAR_CaMKII_strong_coupling Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PP2A	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.1111	0.09	No

PP2A acting as an Enzyme in  AMPAR_CaMKII_strong_coupling Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP2A / PP2A-dephosph-I1	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	15.9999	2	4.1667	explicit E-S complex	Substrate I1* Product I1
	PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
2	PP2A / PP2A-dephosph-PP 1-I*	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	15.9999	2	4.1667	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
	k1 changed from 3.3e-6 to 6.6e-6
3	PP2A / PP2A-dephosph-I1 _ PSD	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	15.9999	2	4.1667	explicit E-S complex	Substrate I1* Product I1
	PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
4	PP2A / PP2A-dephosph-PP 1-I*_ PSD	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	15.9999	2	4.1667	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
	k1 changed from 3.3e-6 to 6.6e-6