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Molecule Parameter List for R2C2-cAMP2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
R2C2-cAMP2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    strong_coupling
    		• 64Network
    Shared_Object_AMPAR_CaMKII_strong_coupling,  CaMKII,  CaM,  
    PP1,  AMPAR_memb,  PP2B,  
    PKA,  AC,  PP1_PSD,  
    AMPAR 
    This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

    R2C2-cAMP2 acting as a Molecule in      AMPAR_CaMKII_strong_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    R2C2-cAMP2
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
    		• PKA
    Pathway No. : 277    		00.09No

    R2C2-cAMP2 acting as a Substrate in a reaction in      AMPAR_CaMKII_strong_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • cAMP-bind-site-A
    1
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
    		• PKA
    Pathway No. : 277    		75.0006
    (uM^-1 s^-1)    		110
    (s^-1)    		Kd(bf) = 1.4667(uM)-Substrate
    R2C2-cAMP2
    cAMP

    Product
    R2C2-cAMP3

    R2C2-cAMP2 acting as a Product in a reaction in      AMPAR_CaMKII_strong_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • cAMP-bind-site-B
    2
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
    		• PKA
    Pathway No. : 277    		54
    (uM^-1 s^-1)    		33
    (s^-1)    		Kd(bf) = 0.6111(uM)-Substrate
    R2C2-cAMP
    cAMP

    Product
    R2C2-cAMP2
    For now let us set this to the same Km (1e-7M) as site B. This gives kf/kb = .7e-7M * 1e6 / (6e5^2) : 1/(6e5^2) = 2e-13:2.77e-12 Smith et al have better values. They say that this is cooperative, so the consts are now kf/kb =8.3e-4


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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