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Molecule Parameter List for AC2 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color. | Statistics | Accession and Pathway Details | |
Accession Name | Accession No. | Accession Type | Pathway Link | AMPAR_CaMKII_ strong_coupling | 64 | Network | Shared_Object_AMPAR_CaMKII_strong_coupling, CaMKII, CaM, PP1, AMPAR_memb, PP2B, PKA, AC, PP1_PSD, AMPAR | This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on. |
AC2 acting as a Molecule in AMPAR_CaMKII_strong_coupling Network
Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | AC2 | AMPAR_CaMKII_ strong_coupling Accession No. : 64 | AC Pathway No. : 278 | 0.0741 | 0.09 | No | Starting at 0.015 uM. 17 Feb 2005: Raised slightly so as to have integer number of molecules. 18 Feb 2005: Doubled, to compensate for reduced ATP. |
AC2 acting as a Substrate for an Enzyme in AMPAR_CaMKII_strong_coupling Network
Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PKC-active / phosph-AC2 | AMPAR_CaMKII_ strong_coupling Accession No. : 64 | Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271 | 33.3337 | 4 | 4 | explicit E-S complex | Substrate AC2
Product AC2*
| Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4 |
AC2 acting as a Product in a reaction in AMPAR_CaMKII_strong_coupling Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | dephosph-AC2 | AMPAR_CaMKII_ strong_coupling Accession No. : 64 | AC Pathway No. : 278 | 0.1 (s^-1) | 0 (s^-1) | - | - | Substrate AC2*
Product AC2
| Random rate. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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