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Molecule Parameter List for CaMKII-thr286-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaMKII-thr286-PSD* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	2	0	3	3	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_CaMKII_ strong_coupling	64	Network	Shared_Object_AMPAR_CaMKII_strong_coupling, CaMKII, CaM, PP1, AMPAR_memb, PP2B, PKA, AC, PP1_PSD, AMPAR
This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

CaMKII-thr286-PSD acting as a Molecule in AMPAR_CaMKII_strong_coupling Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII-thr286-PSD	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0	0.01	No

CaMKII-thr286-PSD acting as a Summed Molecule in AMPAR_CaMKII_strong_coupling Network

	Accession Nane	Pathway Name	Target	Input
1	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	tot-auto-PSD	CaMKII-thr286-PS D CaMKII***-PSD basal_CaMKII_ PSD
2	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	286P-PSD	CaMKII-thr286-Ca M-PSD CaMKII-thr286-PS D

CaMKII-thr286-PSD acting as a Substrate for an Enzyme in AMPAR_CaMKII_strong_coupling Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot-auto-PSD / auton-305-PSD	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	500	6	4	explicit E-S complex	Substrate CaMKII-thr286-PS D Product CaMKII***-PSD
2	PP1-active_PSD / Deph-thr286b	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII-thr286-PS D Product CaMKII-PSD
3	tot-CaM-CaMKII-P SD / CaM-act-305-PSD	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	320	6	4	explicit E-S complex	Substrate CaMKII-thr286-PS D Product CaMKII***-PSD

CaMKII-thr286-PSD acting as a Product of an Enzyme in AMPAR_CaMKII_strong_coupling Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot-auto-PSD / auton-autoph	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	500.005	2	4	explicit E-S complex	Substrate CaMKII-PSD Product CaMKII-thr286-PS D
2	PP1-active_PSD / Deph-thr305	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII*-PSD Product** CaMKII-thr286-PS D
3	tot-CaM-CaMKII-P SD / CaM_act_autoph	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	320.002	2	4	explicit E-S complex	Substrate CaMKII-PSD Product CaMKII-thr286-PS D

CaMKII-thr286-PSD acting as a Substrate in a reaction in AMPAR_CaMKII_strong_coupling Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CaMKII-thr286-bi nd-CaM-PSD	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	1000.02 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0001(uM)	-	Substrate CaM-Ca4-PSD CaMKII-thr286-PS D Product CaMKII-thr286-Ca M-PSD
Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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