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Molecule Parameter List for CaMKII-thr305-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII-thr305-PSD participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1101110

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    strong_coupling
    		• 64Network
    Shared_Object_AMPAR_CaMKII_strong_coupling,  CaMKII,  CaM,  
    PP1,  AMPAR_memb,  PP2B,  
    PKA,  AC,  PP1_PSD,  
    AMPAR 
    This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

    CaMKII-thr305-PSD acting as a Molecule in      AMPAR_CaMKII_strong_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    CaMKII-thr305-PSD
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• 00.01No

    CaMKII-thr305-PSD acting as a Summed Molecule in      AMPAR_CaMKII_strong_coupling Network
    Accession NamePathway NameTargetInput
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• tot_CaMKII_PSDactCaMKII-PSD
    CaMKII-PSD
  • CaMKII-thr305-PS
    D

    • CaMKII-thr305-PSD acting as a Substrate for an Enzyme in      AMPAR_CaMKII_strong_coupling Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active_PSD  /
    Deph-thr305a
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• 2.000010.24explicit E-S complexSubstrate
  • CaMKII-thr305-PS
    D

    Product
    CaMKII-PSD

    • CaMKII-thr305-PSD acting as a Product of an Enzyme in      AMPAR_CaMKII_strong_coupling Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active_PSD  /
    Deph-thr286c
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• 2.000010.24explicit E-S complexSubstrate
    CaMKII***-PSD

    Product
  • CaMKII-thr305-PS
    D

    • CaMKII-thr305-PSD acting as a Substrate in a reaction in      AMPAR_CaMKII_strong_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    back_2
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• 0.3
    (s^-1)    		0
    (#^-1 s^-1)    		Not applicable**-Substrate
  • CaMKII-thr305-PS
    D

    Product
    CaMK-thr305
    NMDAR
    • Same as for back_1
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration


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