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Molecule Parameter List for tot_CaM_CaMKII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

tot_CaM_CaMKII participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	2	2	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_CaMKII_ strong_coupling	64	Network	Shared_Object_AMPAR_CaMKII_strong_coupling,  CaMKII,  CaM,   PP1,  AMPAR_memb,  PP2B,   PKA,  AC,  PP1_PSD,   AMPAR
This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

tot_CaM_CaMKII acting as a Molecule in  AMPAR_CaMKII_strong_coupling Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
tot_CaM_CaMKII	AMPAR_CaMKII_ strong_coupling Accession No. : 64	CaMKII Pathway No. : 272	0	0.09	No

tot_CaM_CaMKII acting as a Summed Molecule in  AMPAR_CaMKII_strong_coupling Network

	Accession Nane	Pathway Name	Target	Input
1	AMPAR_CaMKII_ strong_coupling Accession No. : 64	CaMKII Pathway No. : 272	tot_CaM_CaMKII	CaMKII-CaM CaMKII-thr286*-C aM
2	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	act_CaMKII_cyt	tot_CaM_CaMKII tot_autonomous_ CaMKII

tot_CaM_CaMKII acting as an Enzyme in  AMPAR_CaMKII_strong_coupling Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot_CaM_CaMKII / CaM_act_305	AMPAR_CaMKII_ strong_coupling Accession No. : 64	CaMKII Pathway No. : 272	226.998	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
2	tot_CaM_CaMKII / CaM_act_286	AMPAR_CaMKII_ strong_coupling Accession No. : 64	CaMKII Pathway No. : 272	226.998	0.5	4	explicit E-S complex	Substrate CaMKII-CaM Product CaMKII-thr286*-C aM