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Molecule Parameter List for tot_CaM_CaMKII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
tot_CaM_CaMKII participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1220000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    strong_coupling
    		• 64Network
    Shared_Object_AMPAR_CaMKII_strong_coupling,  CaMKII,  CaM,  
    PP1,  AMPAR_memb,  PP2B,  
    PKA,  AC,  PP1_PSD,  
    AMPAR 
    This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

    tot_CaM_CaMKII acting as a Molecule in      AMPAR_CaMKII_strong_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    tot_CaM_CaMKII
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
    		• CaMKII
    Pathway No. : 272    		00.09No

    tot_CaM_CaMKII acting as a Summed Molecule in      AMPAR_CaMKII_strong_coupling Network
     Accession NanePathway NameTargetInput
    1
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
    		• CaMKII
    Pathway No. : 272    		tot_CaM_CaMKIICaMKII-CaM
  • CaMKII-thr286*-C
    aM
    • 2
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. : 271
    		• act_CaMKII_cyttot_CaM_CaMKII
  • tot_autonomous_
    CaMKII

    • tot_CaM_CaMKII acting as an Enzyme in      AMPAR_CaMKII_strong_coupling Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot_CaM_CaMKII /
    CaM_act_305
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
    		• CaMKII
    Pathway No. : 272    		226.99864explicit E-S complexSubstrate
    CaMKII-thr286

    Product
    CaMKII***
        Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
    2tot_CaM_CaMKII /
    CaM_act_286
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. : 64
    		• CaMKII
    Pathway No. : 272    		226.9980.54explicit E-S complexSubstrate
    CaMKII-CaM

    Product
  • CaMKII-thr286*-C
    aM


    • Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.