Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

Search in:

ALL Accession Pathway Molecule Enzyme Reaction Connected to

Search for

Match

Anything Exact Word Starting With

By

Name Notes Model

Molecule Parameter List for SOCS1-IFNRJ2*-STAT1c

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

SOCS1-IFNRJ2*-STAT1c participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	2	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Jak-Stat_ Pathway	66	Pathway	Jak-Stat_Pathway
This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6 This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. Note: There are a few ambiguities in the paper like initial concentration of IFN and some reactions were missing in the paper that were employed for obtaining the results. The graphs are almost similar to the graphs as shown in the paper but still some ambiguities regarding the concentration are there. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.

SOCS1-IFNRJ2*-STAT1c acting as a Molecule in  Jak-Stat_Pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
SOCS1-IFNRJ2*-STAT1c	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	0	0.0016667	No
STAT1 bound to SOCS1 complexed with phosphorylated IFNRJ dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

SOCS1-IFNRJ2*-STAT1c acting as a Substrate in a reaction in  Jak-Stat_Pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	SHP-2_ binding[1]	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	1 (uM^-1 s^-1)	0.2 (s^-1)	Kd(bf) = 0.2(uM)	-	Substrate SHP-2 SOCS1-IFNRJ2*-ST AT1c Product SOCS1-IFNRJ2*-ST AT1c-SHP-2
	Binding of SHP-2 to JAK-IFNR phosphorylated dimer complexed with SOCS1 and STAT1c Kf = 1*10e+06 /M/sec = 1/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
2	SOCS1_unbind	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	0.0005 (s^-1)	0 (s^-1)	-	-	Substrate SOCS1-IFNRJ2*-ST AT1c Product IFNRJ2*-STAT1c
	Unbinding reaction of the SOCS1 from SOCS1-IFNRJ2*-STAT1c kf = 0.0005/sec kb =0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.

SOCS1-IFNRJ2*-STAT1c acting as a Product in a reaction in  Jak-Stat_Pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	STAT1c_ binding[2]	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	8 (uM^-1 s^-1)	0.8 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate SOCS1-IFNRJ2* STAT1c Product SOCS1-IFNRJ2*-ST AT1c
	Binding of STAT1c to JAK-IFNR phosphorylated dimer complexed with SOCS1 Kf = 8*10e+06 /M/sec = 8/uM/sec Kb = 0.8 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
2	SOCS1c_ binding[2]	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	20 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate IFNRJ2*-STAT1c SOCS1 Product SOCS1-IFNRJ2*-ST AT1c
	Binding reaction of SOCS1+IFNRJ2*-STAT1c kf = 20/sec/uM kb = 0.1/sec Appendix,Satoshi Yamada et al 2003 FEBS Letters 534:190-196.