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Molecule Parameter List for SOCS1-IFNRJ2*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
SOCS1-IFNRJ2* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000031

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Jak-Stat_
    Pathway
  • 66Pathway
    Jak-Stat_Pathway 
    This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
    This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway.
    Note: There are a few ambiguities in the paper like initial concentration of IFN and some reactions were missing in the paper that were employed for obtaining the results. The graphs are almost similar to the graphs as shown in the paper but still some ambiguities regarding the concentration are there. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.

    SOCS1-IFNRJ2* acting as a Molecule in  
    Jak-Stat_Pathway Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    SOCS1-IFNRJ2*
  • Jak-Stat_
    Pathway

    Accession No. : 66
  • Jak-Stat_
    Pathway

    Pathway No. : 293
  • 00.0016667No
    SOCS1 complexed with phosphorylated IFNRJ dimer. Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

    SOCS1-IFNRJ2* acting as a Substrate in a reaction in  
    Jak-Stat_Pathway Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1
  • STAT1c_
    binding[2]
  • Jak-Stat_
    Pathway

    Accession No. : 66
  • Jak-Stat_
    Pathway

    Pathway No. : 293
  • 8
    (uM^-1 s^-1)
    0.8
    (s^-1)
    Kd(bf) = 0.1(uM)-Substrate
    SOCS1-IFNRJ2*
    STAT1c

    Product
  • SOCS1-IFNRJ2*-ST
    AT1c

  •   Binding of STAT1c to JAK-IFNR phosphorylated dimer complexed with SOCS1 Kf = 8*10e+06 /M/sec = 8/uM/sec Kb = 0.8 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    2unbind_SOCS1[1]
  • Jak-Stat_
    Pathway

    Accession No. : 66
  • Jak-Stat_
    Pathway

    Pathway No. : 293
  • 0.0005
    (s^-1)
    0
    (s^-1)
    --Substrate
    SOCS1-IFNRJ2*

    Product
    IFNRJ2*
      The unbinding reactoion of SOCS1 from SOCS1-IFNRJ2* kf = 0.0005/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
    3SHP2_binding[2]
  • Jak-Stat_
    Pathway

    Accession No. : 66
  • Jak-Stat_
    Pathway

    Pathway No. : 293
  • 1
    (uM^-1 s^-1)
    0.2
    (s^-1)
    Kd(bf) = 0.2(uM)-Substrate
    SHP-2
    SOCS1-IFNRJ2*

    Product
  • SOCS1-IFNRJ2*-SH
    P2

  •   SHP2 binding reaction to SOCS1-IFNRJ2* kf = 1/sec/uM kb = 0.2/sec Appendix,Satoshi Yamada et al 2003 FEBS LEtters 534:190-196.

    SOCS1-IFNRJ2* acting as a Product in a reaction in  
    Jak-Stat_Pathway Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • SOCS1_
    binding[1]
  • Jak-Stat_
    Pathway

    Accession No. : 66
  • Jak-Stat_
    Pathway

    Pathway No. : 293
  • 20
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    IFNRJ2*
    SOCS1

    Product
    SOCS1-IFNRJ2*
    Binding of SOCS1 to phosphorylated dimer of IFN gamma liganding to the IFN gamma receptor that has JAK bound to its intracellular domain Kf = 20*10e+06 /M/sec = 20/uM/sec Kb = 0.1 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196



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