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Molecule Parameter List for Lambda-cl_operator | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lambda-cl_operator participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| Repressilator | 68 | Network | Lambda-cl_gene, Lac_gene, TetR_gene |
| This is a network model termed as Repressilator in which LacI inhibit transcription of tetR which in turn inhibit transcription of Lambda phage. This model simulates the result as per the Fig 1c of the paper : Elowitz MB, Leibler S., Nature. 2000 Jan 20;403(6767):335-8. | |||
Lambda-cl_operator acting as a Molecule in Repressilator Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| Lambda-cl_operator | Repressilator Accession No. : 68 | Lambda-cl_gene Pathway No. : 295 | 0.0222 | 3 | No | |
| The lambda cl operator under normal conditions drives transcription of lambda cl Elowitz, M. et al. (2000) Nature 403:335-338 | ||||||
Lambda-cl_operator acting as an Enzyme in Repressilator Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
operator / basal_ transcription | Repressilator Accession No. : 68 | Lambda-cl_gene Pathway No. : 295 | 0.0005556 | 0.5 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | Substrate Nucleotides Product lambda-cl_mRNA |
| Basal transcription of the Lambda cl gene. Rates from Box 1 Elowitz, M. et al. (2000) Nature 403:335-338 | |||||||
Lambda-cl_operator acting as a Substrate in a reaction in Repressilator Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
operator_ inhibition_ reaction | Repressilator Accession No. : 68 | Lambda-cl_gene Pathway No. : 295 | 1000.01 (uM^-1 s^-1) | 224 (s^-1) | Kd(bf) = 0.224(uM) | - | Substrate operator TetR Product operator_1st_ bound |
| It signifies the first binding of the repressor with the operator Kf = 1 /nM/sec Kb = 224 /sec Box 1 Elowitz, M. et al. (2000) Nature 403:335-338 | |||||||