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Molecule Parameter List for RCC1-Ran

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
RCC1-Ran participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
RanGTPase70Network
Shared_Object_RanGTPase,  Nucleus,  Cytoplasm 
This model represents a concentration gradient of RanGTP across the nuclear envelope. This gradient is generated by distribution of regulators of RanGTPase. We have taken a log linear plot of graphs generated by GENESIS and compared with the experimental graphs.

RCC1-Ran acting as a Molecule in  RanGTPase Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
RCC1-RanRanGTPase
Accession No. : 70		Nucleus
Pathway No. : 305		012000No
RCC1-GDP.Ran Ran-GDP complex bound to RCC1 Nuclear volume = 1.2pL = 1.2e-15 m^3 Footnote for Table 2 Gorlich D et al (2003) EMBO J 22(5):1088-1100

RCC1-Ran acting as a Substrate in a reaction in  RanGTPase Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
GTP_bindingRanGTPase
Accession No. : 70		Nucleus
Pathway No. : 305		0.6
(uM^-1 s^-1)		19
(s^-1)		Kd(bf) = 31.6669(uM)-Substrate
GTP
RCC1-Ran

Product
RCC1-RanGTP
Binding of GTP to GDP free Ran-RCC1 complex Kf = 0.6e+06 /M/sec = 0.6 /uM/sec Kb = 19 /sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100

RCC1-Ran acting as a Product in a reaction in  RanGTPase Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
  • GDP_
    dissociation
    		• RanGTPase
    Accession No. : 70    		Nucleus
    Pathway No. : 305    		21
    (s^-1)    		11
    (uM^-1 s^-1)    		Kd(cb) = 0.5238(uM)-Substrate
    RCC1-GDP.Ran

    Product
    GDP
    RCC1-Ran
    Release of GDP from the GDP-Ran complex with RCC1 Kf = 21 /sec Kb = 1.1e+07 /M/sec = 1.1e+01 /uM/sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100


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