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Molecule Parameter List for GTP.Ran-nuclear

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
GTP.Ran-nuclear participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
RanGTPase70Network
Shared_Object_RanGTPase,  Nucleus,  Cytoplasm 
This model represents a concentration gradient of RanGTP across the nuclear envelope. This gradient is generated by distribution of regulators of RanGTPase. We have taken a log linear plot of graphs generated by GENESIS and compared with the experimental graphs.

GTP.Ran-nuclear acting as a Molecule in  RanGTPase Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
GTP.Ran-nuclearRanGTPase
Accession No. : 70		Nucleus
Pathway No. : 305		012000No
nuclear-GTP.Ran Nuclear fraction of Ran-GTP complex Nuclear volume = 1.2 pL = 1.2e-15 m^3 Footnote for Table 2 Gorlich D et al (2003) EMBO J 22(5):1088-1100

GTP.Ran-nuclear acting as a Substrate in a reaction in  RanGTPase Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
  • Cytoplasmic_
    transfer
    		• RanGTPase
    Accession No. : 70
  • Shared_Object_
    RanGTPase
    Pathway No. : 304
    		• 0.08
    (s^-1)    		1.3
    (s^-1)    		Not applicable**-Substrate
    GTP.Ran-nuclear

    Product
  • GTP.Ran-cytoplas
    mic
    • Approximation to achieve Cytoplasmic transfer as per kinetics described by Gorlich D et al (2003) EMBO J 22(5):1088-1100
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

    GTP.Ran-nuclear acting as a Product in a reaction in      RanGTPase Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    GTP.Ran_releaseRanGTPase
    Accession No. : 70    		Nucleus
    Pathway No. : 305    		55
    (s^-1)    		99.9994
    (uM^-1 s^-1)    		Kd(cb) = 1.8182(uM)-Substrate
    RCC1-RanGTP

    Product
    GTP.Ran-nuclear
    RCC1
    Release of GTP.Ran from GTP.Ran-RCC1 complex Kf = 55 /sec Kb = 1.0e+08 /M/sec = 1.0e+02 /uM/sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100


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