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Molecule Parameter List for nuclear-NTF2-GDP.Ran

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

nuclear-NTF2-GDP.Ran participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
RanGTPase	70	Network	Shared_Object_RanGTPase,  Nucleus,  Cytoplasm
This model represents a concentration gradient of RanGTP across the nuclear envelope. This gradient is generated by distribution of regulators of RanGTPase. We have taken a log linear plot of graphs generated by GENESIS and compared with the experimental graphs.

nuclear-NTF2-GDP.Ran acting as a Molecule in  RanGTPase Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
nuclear-NTF2-GDP.Ran	RanGTPase Accession No. : 70	Nucleus Pathway No. : 305	0	12000	No
NTF2-GDP.Ran Cytoplasmic fraction of GDP bound Ran complexed with NTF2 Nuclear volume = 1.2 pL = 1.2e-15 m^3 Footnote for Table 2 Gorlich D et al (2003) EMBO J 22(5):1088-1100 Initial cytoplasmic GDP.Ran concentration = 5 uM Table II footnote

nuclear-NTF2-GDP.Ran acting as a Substrate in a reaction in  RanGTPase Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
NTF2_ dissociation[1]	RanGTPase Accession No. : 70	Nucleus Pathway No. : 305	0.48 (s^-1)	0 (#^-1 s^-1)	Not applicable**	-	Substrate nuclear-NTF2-GDP .Ran Product GDP.Ran-nuclear NTF2
Approximation of reaction rates to match the kinetics described by Gorlich D et al (2003) EMBO J 22(5):1088-1100

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

nuclear-NTF2-GDP.Ran acting as a Product in a reaction in  RanGTPase Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Nucleoplasmic_ transfer	RanGTPase Accession No. : 70	Shared_Object_ RanGTPase Pathway No. : 304	10000 (s^-1)	0.1 (s^-1)	Not applicable**	-	Substrate NTF2-GDP.Ran Product nuclear-NTF2-GDP .Ran
Approximation to achieve Nucleoplasmic transfer as per kinetics described by Gorlich D et al (2003) EMBO J 22(5):1088-1100

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration