|
Enter a Search String | | Special character and space not allowed in the query term.
Search string should be at least 2 characters long. |
Molecule Parameter List for nuclear-NTF2-GDP.Ran | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | RanGTPase | 70 | Network |
Shared_Object_RanGTPase, Nucleus, Cytoplasm | | This model represents a concentration gradient of RanGTP across the nuclear envelope. This gradient is generated by distribution of regulators of RanGTPase. We have taken a log linear plot of graphs generated by GENESIS and compared with the experimental graphs. |
nuclear-NTF2-GDP.Ran acting as a Molecule in RanGTPase Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | nuclear-NTF2-GDP.Ran | RanGTPase
Accession No. : 70 | Nucleus
Pathway No. : 305 | 0 | 12000 | No | | NTF2-GDP.Ran Cytoplasmic fraction of GDP bound Ran complexed with NTF2 Nuclear volume = 1.2 pL = 1.2e-15 m^3 Footnote for Table 2 Gorlich D et al (2003) EMBO J 22(5):1088-1100 Initial cytoplasmic GDP.Ran concentration = 5 uM Table II footnote |
nuclear-NTF2-GDP.Ran acting as a Substrate in a reaction in RanGTPase Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | NTF2_
dissociation[1] | RanGTPase
Accession No. : 70 | Nucleus
Pathway No. : 305 | 0.48
(s^-1) | 0
(#^-1 s^-1) | Not applicable** | - | Substrate
nuclear-NTF2-GDP
.Ran
Product
GDP.Ran-nuclear
NTF2
| | Approximation of reaction rates to match the kinetics described by Gorlich D et al (2003) EMBO J 22(5):1088-1100 |
** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration
nuclear-NTF2-GDP.Ran acting as a Product in a reaction in RanGTPase Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | Nucleoplasmic_
transfer | RanGTPase
Accession No. : 70 | Shared_Object_
RanGTPase
Pathway No. : 304 | 10000
(s^-1) | 0.1
(s^-1) | Not applicable** | - | Substrate
NTF2-GDP.Ran
Product
nuclear-NTF2-GDP
.Ran
| | Approximation to achieve Nucleoplasmic transfer as per kinetics described by Gorlich D et al (2003) EMBO J 22(5):1088-1100 |
** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
|
