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Molecule Parameter List for RasGTP-NF1* | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RasGTP-NF1* participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| RasGTPase | 71 | Pathway | RasGTPase |
| Ras is an important regulator of cell growth in all eukaryotic cells. The model represent hydrolysis of active Ras-bound GTP to give inactive Ras-bound GDP catalyzed by GTPase activating proteins i.e NF1. The inactive Ras-bound GDP turns signalling protein off. | |||
RasGTP-NF1* acting as a Molecule in RasGTPase Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| RasGTP-NF1* | RasGTPase Accession No. : 71 | RasGTPase Pathway No. : 307 | 0 | 523.6 | No | |
| NF1 bound to activated N-ras complexed to GTP NF1 is a mammalian GAP Phillips RA et al 2003 Biochemistry 42: 3956-3965 | ||||||
RasGTP-NF1* acting as a Substrate in a reaction in RasGTPase Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
hydrolysis[1] | RasGTPase Accession No. : 71 | RasGTPase Pathway No. : 307 | 19.5 (s^-1) | 0.22 (s^-1) | Keq = 0.0113(uM) | 0.051sec | Substrate RasGTP-NF1* Product RasGDP-NF1_Pi |
| First step in hydrolysis of GTP bound to Ras complexed with NF1 - a mammalian GAP Kf = 19.5 /sec Kb = 0.22 /sec Table 3, Phillips RA et al 2003 Biochemistry 42: 3956-3965 | |||||||
RasGTP-NF1* acting as a Product in a reaction in RasGTPase Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| Ras_activation | RasGTPase Accession No. : 71 | RasGTPase Pathway No. : 307 | 418 (s^-1) | 5.5 (s^-1) | Keq = 0.0132(uM) | 0.002sec | Substrate RasGTP-NF1 Product RasGTP-NF1* |
| Activation of Ras by GAP (i.e NF1) Kf = 418 /sec Kb = 5.5 /sec Table 3, Phillips RA et al 2003 Biochemistry 42: 3956-3965 | |||||||