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Molecule Parameter List for RasGTP-NF1* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | RasGTPase | 71 | Pathway |
RasGTPase | | Ras is an important regulator of cell growth in all eukaryotic cells. The model represent hydrolysis of active Ras-bound GTP to give inactive Ras-bound GDP catalyzed by GTPase activating proteins i.e NF1. The inactive Ras-bound GDP turns signalling protein off. |
RasGTP-NF1* acting as a Molecule in RasGTPase Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | RasGTP-NF1* | RasGTPase
Accession No. : 71 | RasGTPase
Pathway No. : 307 | 0 | 523.6 | No | | NF1 bound to activated N-ras complexed to GTP NF1 is a mammalian GAP Phillips RA et al 2003 Biochemistry 42: 3956-3965 |
RasGTP-NF1* acting as a Substrate in a reaction in RasGTPase Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | GTP_
hydrolysis[1] | RasGTPase
Accession No. : 71 | RasGTPase
Pathway No. : 307 | 19.5
(s^-1) | 0.22
(s^-1) | Keq = 0.0113(uM) | 0.051sec | Substrate
RasGTP-NF1*
Product
RasGDP-NF1_Pi
| | First step in hydrolysis of GTP bound to Ras complexed with NF1 - a mammalian GAP Kf = 19.5 /sec Kb = 0.22 /sec Table 3, Phillips RA et al 2003 Biochemistry 42: 3956-3965 |
RasGTP-NF1* acting as a Product in a reaction in RasGTPase Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | Ras_activation | RasGTPase
Accession No. : 71 | RasGTPase
Pathway No. : 307 | 418
(s^-1) | 5.5
(s^-1) | Keq = 0.0132(uM) | 0.002sec | Substrate
RasGTP-NF1
Product
RasGTP-NF1*
| | Activation of Ras by GAP (i.e NF1) Kf = 418 /sec Kb = 5.5 /sec Table 3, Phillips RA et al 2003 Biochemistry 42: 3956-3965 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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