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Molecule Parameter List for NF1 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | RasGTPase | 71 | Pathway |
RasGTPase | | Ras is an important regulator of cell growth in all eukaryotic cells. The model represent hydrolysis of active Ras-bound GTP to give inactive Ras-bound GDP catalyzed by GTPase activating proteins i.e NF1. The inactive Ras-bound GDP turns signalling protein off. |
NF1 acting as a Molecule in RasGTPase Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | NF1 | RasGTPase
Accession No. : 71 | RasGTPase
Pathway No. : 307 | 9.9994 | 523.6 | No | | Neurofibromin a mammalian GAP NF1 conc = 10 um pp.3959 Refer: Phillips RA et al 2003 Biochemistry 42: 3956-3965 |
NF1 acting as a Substrate in a reaction in RasGTPase Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | NF1_binding | RasGTPase
Accession No. : 71 | RasGTPase
Pathway No. : 307 | 1.2
(uM^-1 s^-1) | 6.36
(s^-1) | Kd(bf) = 5.3(uM) | - | Substrate
NF1
RasGTP
Product
RasGTP-NF1
| | Binding of NF1 to Ras.GTP NF1 is a mammalian GAP Kd = 5.3 uM Table 3, Phillips RA et al 2003 Biochemistry 42: 3956-3965 |
NF1 acting as a Product in a reaction in RasGTPase Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | GAP_
dissociation | RasGTPase
Accession No. : 71 | RasGTPase
Pathway No. : 307 | 46.5
(s^-1) | 1.2
(uM^-1 s^-1) | Kd(cb) = 0.0258(uM) | - | Substrate
RasGDP_NF1
Product
NF1
RasGDP
| | Dissociation of NF1 from Ras.GDP NF1 is a mammalian GAP Kf = 46.5 /sec Kb = 1.2 /sec/uM Table 3, Phillips RA et al 2003 Biochemistry 42: 3956-3965 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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