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Molecule Parameter List for CaMKII***

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

CaMKII*** participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	2	2	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_Bhalla_ 2004_PKM_Tuning	76	Network	PKC, Shared_Object_Ajay_Bhalla_2004_PKM_tuning, PLA2, PLCbeta, Gq, MAPK, Ras, EGFR, Sos, PLC_g, CaMKII, CaM, PP1, PP2B, PKA, AC, PKM
This model is taken from the Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the reference feedforward model from Figure 8a.

CaMKII*** acting as a Molecule in Ajay_Bhalla_2004_PKM_Tuning Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII***	Ajay_Bhalla_ 2004_PKM_Tuning Accession No. : 76	CaMKII Pathway No. : 322	0	1.5	No
From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.

CaMKII*** acting as a Summed Molecule in Ajay_Bhalla_2004_PKM_Tuning Network

Accession Name	Pathway Name	Target	Input
Ajay_Bhalla_ 2004_PKM_Tuning Accession No. : 76	CaMKII Pathway No. : 322	tot_autonomous_CaMKII	CaMKII-thr286 CaMKII***

CaMKII*** acting as a Substrate for an Enzyme in Ajay_Bhalla_2004_PKM_Tuning Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP1-active / Deph-thr305	Ajay_Bhalla_ 2004_PKM_Tuning Accession No. : 76	Shared_Object_ Ajay_Bhalla_ 2004_PKM_tuning Pathway No. : 312	5.09911	0.35	4	explicit E-S complex	Substrate CaMKII* Product** CaMKII-thr286

2	PP1-active / Deph-thr286c	Ajay_Bhalla_ 2004_PKM_Tuning Accession No. : 76	Shared_Object_ Ajay_Bhalla_ 2004_PKM_tuning Pathway No. : 312	5.09911	0.35	4	explicit E-S complex	Substrate CaMKII* Product** CaMK-thr306

CaMKII*** acting as a Product of an Enzyme in Ajay_Bhalla_2004_PKM_Tuning Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot_CaM_CaMKII / CaM_act_305	Ajay_Bhalla_ 2004_PKM_Tuning Accession No. : 76	CaMKII Pathway No. : 322	113.599	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
2	tot_autonomous_ CaMKII / auton_305	Ajay_Bhalla_ 2004_PKM_Tuning Accession No. : 76	CaMKII Pathway No. : 322	175.006	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***
	See Hanson and Schulman again, for afterburst rates of phosph.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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