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Molecule Parameter List for tot_CaM_CaMKII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
tot_CaM_CaMKII participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1120000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2004_PKM_Tuning
    		• 76Network
    PKC,  Shared_Object_Ajay_Bhalla_2004_PKM_tuning,  PLA2,  
    PLCbeta,  Gq,  MAPK,  
    Ras,  EGFR,  Sos,  
    PLC_g,  CaMKII,  CaM,  
    PP1,  PP2B,  PKA,  
    AC,  PKM 
    This model is taken from the Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the reference feedforward model from Figure 8a.

    tot_CaM_CaMKII acting as a Molecule in      Ajay_Bhalla_2004_PKM_Tuning Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    tot_CaM_CaMKII
  • Ajay_Bhalla_
    2004_PKM_Tuning
    Accession No. : 76
    		• CaMKII
    Pathway No. : 322    		01.5No

    tot_CaM_CaMKII acting as a Summed Molecule in      Ajay_Bhalla_2004_PKM_Tuning Network
    Accession NamePathway NameTargetInput
  • Ajay_Bhalla_
    2004_PKM_Tuning
    Accession No. : 76
    		• CaMKII
    Pathway No. : 322    		tot_CaM_CaMKIICaMKII-CaM
  • CaMKII-thr286*-C
    aM

    • tot_CaM_CaMKII acting as an Enzyme in      Ajay_Bhalla_2004_PKM_Tuning Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot_CaM_CaMKII /
    CaM_act_305
  • Ajay_Bhalla_
    2004_PKM_Tuning
    Accession No. : 76
    		• CaMKII
    Pathway No. : 322    		113.59964explicit E-S complexSubstrate
    CaMKII-thr286

    Product
    CaMKII***
        Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
    2tot_CaM_CaMKII /
    CaM_act_286
  • Ajay_Bhalla_
    2004_PKM_Tuning
    Accession No. : 76
    		• CaMKII
    Pathway No. : 322    		113.6010.54explicit E-S complexSubstrate
    CaMKII-CaM

    Product
  • CaMKII-thr286*-C
    aM
    •    


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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