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Molecule Parameter List for PKC-DAG-AA

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

PKC-DAG-AA participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_Bhalla_ 2004_Feedback_ Tuning	78	Network	Shared_Object_Ajay_Bhalla_2004_Feedback_Tuning,  PKC,  PLA2,   PLCbeta,  Gq,  MAPK,   Ras,  EGFR,  Sos,   PLC_g,  CaMKII,  CaM,   PP1,  PP2B,  PKA,   AC
This model is taken from Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedback model from Figure 8a.

PKC-DAG-AA acting as a Molecule in  Ajay_Bhalla_2004_Feedback_Tuning Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PKC-DAG-AA	Ajay_Bhalla_ 2004_Feedback_ Tuning Accession No. : 78	PKC Pathway No. : 348	0	1.5	No

PKC-DAG-AA acting as a Substrate in a reaction in  Ajay_Bhalla_2004_Feedback_Tuning Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
PKC-act-by-DAG-A A	Ajay_Bhalla_ 2004_Feedback_ Tuning Accession No. : 78	PKC Pathway No. : 348	2 (s^-1)	0.2 (s^-1)	Keq = 0.1(uM)	0.455sec	Substrate PKC-DAG-AA Product PKC-DAG-AA*
Assume slowish too. Schaechter and Benowitz

PKC-DAG-AA acting as a Product in a reaction in  Ajay_Bhalla_2004_Feedback_Tuning Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
PKC-n-DAG-AA	Ajay_Bhalla_ 2004_Feedback_ Tuning Accession No. : 78	PKC Pathway No. : 348	0.018 (uM^-1 s^-1)	2 (s^-1)	Kd(bf) = 111.1111(uM)	-	Substrate AA PKC-DAG Product PKC-DAG-AA
Reduced kf to 0.66X to match Shinomura et al data. Initial: kf = 3.3333e-9 New: 2e-9 Newer: 2e-8 kb was 0.2 now 2.