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Molecule Parameter List for G*GDP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
G*GDP participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000012

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    		• 78Network
    Shared_Object_Ajay_Bhalla_2004_Feedback_Tuning,  PKC,  PLA2,  
    PLCbeta,  Gq,  MAPK,  
    Ras,  EGFR,  Sos,  
    PLC_g,  CaMKII,  CaM,  
    PP1,  PP2B,  PKA,  
    AC 
    This model is taken from Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedback model from Figure 8a.

    G*GDP acting as a Molecule in      Ajay_Bhalla_2004_Feedback_Tuning Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    G*GDP
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Accession No. : 78
  • Shared_Object_
    Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Pathway No. : 347
    		• 01.5No

    G*GDP acting as a Substrate in a reaction in      Ajay_Bhalla_2004_Feedback_Tuning Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Trimerize-G
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Accession No. : 78
    		• Gq
    Pathway No. : 351    		6
    (uM^-1 s^-1)    		0
    (s^-1)    		--Substrate
    BetaGamma
    G*GDP

    Product
    G-GDP
    kf == kg3 = 1e-5 /cell/sec. As usual, there is no back-reaction kb = 0

    G*GDP acting as a Product in a reaction in      Ajay_Bhalla_2004_Feedback_Tuning Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Inact-PLC-Gq
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Accession No. : 78
    		• PLCbeta
    Pathway No. : 350    		0.0133
    (s^-1)    		0
    (uM^-1 s^-1)    		--Substrate
    PLC-Ca-Gq

    Product
    G*GDP
    PLC-Ca
      This process is assumed to be directly caused by the inactivation of the G*GTP to G*GDP. Hence, kf = .013 /sec = 0.8/min, same as the rate for Inact-G. kb = 0 since this is irreversible. We may be interested in studying the role of PLC as a GAP. If so, the kf would be faster here than in Inact-G
    2Inact-G
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Accession No. : 78
    		• Gq
    Pathway No. : 351    		0.0133
    (s^-1)    		0
    (s^-1)    		--Substrate
    G*GTP

    Product
    G*GDP
      From Berstein et al JBC 267:12 8081-8088 1992, kcat for GTPase activity of Gq is only 0.8/min


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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