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Molecule Parameter List for neurogranin-CaM

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
neurogranin-CaM participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    		• 78Network
    Shared_Object_Ajay_Bhalla_2004_Feedback_Tuning,  PKC,  PLA2,  
    PLCbeta,  Gq,  MAPK,  
    Ras,  EGFR,  Sos,  
    PLC_g,  CaMKII,  CaM,  
    PP1,  PP2B,  PKA,  
    AC 
    This model is taken from Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedback model from Figure 8a.

    neurogranin-CaM acting as a Molecule in      Ajay_Bhalla_2004_Feedback_Tuning Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    neurogranin-CaM
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Accession No. : 78
    		• CaM
    Pathway No. : 358    		01.5No

    neurogranin-CaM acting as a Substrate for an Enzyme in      Ajay_Bhalla_2004_Feedback_Tuning Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PKC-active  /
  • PKC-phosph-ng-Ca
    M
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Accession No. : 78
  • Shared_Object_
    Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Pathway No. : 347
    		• 28.59480.354explicit E-S complexSubstrate
    neurogranin-CaM

    Product
    CaM
    neurogranin*
    Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993

    neurogranin-CaM acting as a Product in a reaction in      Ajay_Bhalla_2004_Feedback_Tuning Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • neurogranin-bind
    -CaM
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Accession No. : 78
    		• CaM
    Pathway No. : 358    		0.3
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 3.3334(uM)-Substrate
    CaM
    neurogranin

    Product
    neurogranin-CaM
    Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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