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Molecule Parameter List for PKC-Ca-AA*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKC-Ca-AA* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1100001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
3d_fold_model8Network
Shared_Object_3d_fold_model,  PKC,  MAPK,  
PLA2,  Ras 
This model is an annotated version of the synaptic signaling network.
The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated Bhalla US, Ram PT, Iyengar R. Science. 2002 Aug 9;297(5583):1018-23.

PKC-Ca-AA* acting as a Molecule in  3d_fold_model Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
PKC-Ca-AA*3d_fold_model
Accession No. : 8		PKC
Pathway No. : 55		01000No

PKC-Ca-AA* acting as a Summed Molecule in  3d_fold_model Network
Accession NamePathway NameTargetInput
3d_fold_model
Accession No. : 8
  • Shared_Object_
    3d_fold_model
    Pathway No. : 54
    		• PKC-activePKC-DAG-AA*
    PKC-Ca-memb*
    PKC-Ca-AA*
    PKC-DAG-memb*
    PKC-basal*
    PKC-AA*
    Conc of PKC in brain is about 1 uM (?)

    PKC-Ca-AA* acting as a Product in a reaction in      3d_fold_model Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • PKC-act-by-Ca-AA
    		• 3d_fold_model
    Accession No. : 8    		PKC
    Pathway No. : 55    		0.0012
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
    Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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