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Molecule Parameter List for PKC-Ca

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKC-Ca participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000031

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
3d_fold_model8Network
Shared_Object_3d_fold_model PKC MAPK 
PLA2 Ras 
This model is an annotated version of the synaptic signaling network.
The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated Bhalla US, Ram PT, Iyengar R. Science. 2002 Aug 9;297(5583):1018-23.

PKC-Ca acting as a Molecule in  
3d_fold_model Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PKC-Ca3d_fold_model
Accession No. : 8
PKC
Pathway No. : 55
01000No

PKC-Ca acting as a Substrate in a reaction in  
3d_fold_model Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
 NameAccession NamePathway NameKfKbKdtauReagents
1PKC-act-by-DAG3d_fold_model
Accession No. : 8
PKC
Pathway No. : 55
0.008
(uM^-1 s^-1)
8.6348
(s^-1)
Kd(bf) = 1079.377(uM)-Substrate
DAG
PKC-Ca

Product
PKC-Ca-DAG
  Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
2PKC-Ca-to-memb3d_fold_model
Accession No. : 8
PKC
Pathway No. : 55
1.2705
(s^-1)
3.5026
(s^-1)
Keq = 2.7569(uM)0.21secSubstrate
PKC-Ca

Product
PKC-Ca-memb*
3
  • PKC-act-by-Ca-AA
  • 3d_fold_model
    Accession No. : 8
    PKC
    Pathway No. : 55
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.

    PKC-Ca acting as a Product in a reaction in  
    3d_fold_model Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    PKC-act-by-Ca3d_fold_model
    Accession No. : 8
    PKC
    Pathway No. : 55
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
    Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5



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