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Molecule Parameter List for CaM

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaM participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences2500004924

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    		• 82NetworkShared_Object_Ajay_Bhalla_2007_ReacDiff1_1e-13,  
    PKC,  MAPK,  Ras,  CaM,  PKM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[1],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[2],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[3],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[4],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[5],  
    PKC,  MAPK,  Ras,  kinetics[6],  CaM,  PKM,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[7],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[8],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[9],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[10],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[11],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[12],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[13],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[14],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[15],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[16],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[17],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[18],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[19],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[20],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[21],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[22],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[23],  
    PKC,  MAPK,  Ras,  CaM,  PKM 
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec.
    The stimulus file pkm_mapk22_diff_1e-13_Fig4B which was used for the model to replicate Figure 4B from the paper.
    pkm_mapk22_diff_1e-13_Fig4H replicate Figure 4H.
    pkm_mapk22_diff_1e-13_Fig4I replicate Figure 4I.

    CaM acting as a Molecule in      Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 530    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 537    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 543    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 549    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 555    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 561    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 568    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 573    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 579    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 585    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 591    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 597    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 603    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 609    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 615    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 621    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 627    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 633    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 639    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 645    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 651    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 657    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 663    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 669    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
    CaM
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 675    		19.99971.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.

    CaM acting as a Substrate in a reaction in      Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    2CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 530    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    3diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    4CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 537    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    5diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    6CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 543    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    7diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    8CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 549    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    10CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 555    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    11diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    12CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 561    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    14CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 568    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    15diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    16CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 573    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    17diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    18CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 579    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    19diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    20CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 585    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    22CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 591    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    23diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    24CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 597    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    25diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    26CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 603    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    27diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    28CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 609    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    29diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    30CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 615    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    31diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    32CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 621    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    33diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    34CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 627    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    35diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    36CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 633    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    37diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    38CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 639    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    39diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    40CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 645    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    41diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    42CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 651    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    43diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    44CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 657    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    45diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    46CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 663    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    47diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    48CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 669    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853
    49CaM-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• CaM
    Pathway No. : 675    		8.4851
    (uM^-1 s^-1)    		8.4853
    (s^-1)    		Kd(bf) = 1(uM)-Substrate
    Ca
    CaM

    Product
    CaM-Ca
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !) 19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into two steps, each binding 1 Ca. This improves numerical stability and is conceptually better too. Overall rates are the same, so each kf and kb is the square root of the earlier ones. So kf = 1.125e-4, kb = 8.4853

    CaM acting as a Product in a reaction in      Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    3diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    5diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    7diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    11diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    15diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    17diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    19diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    23diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM

    Product
    CaM


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