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Molecule Parameter List for DAG

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

DAG participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	25	0	0	0	0	50	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13	82	Network	Shared_Object_Ajay_Bhalla_2007_ReacDiff1_1e-13,   PKC,  MAPK,  Ras,  CaM,  PKM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[1],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[2],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[3],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[4],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[5],   PKC,  MAPK,  Ras,  kinetics[6],  CaM,  PKM,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[7],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[8],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[9],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[10],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[11],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[12],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[13],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[14],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[15],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[16],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[17],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[18],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[19],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[20],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[21],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[22],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[23],   PKC,  MAPK,  Ras,  CaM,  PKM
This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec. The stimulus file pkm_mapk22_diff_1e-13_Fig4B which was used for the model to replicate Figure 4B from the paper. pkm_mapk22_diff_1e-13_Fig4H replicate Figure 4H. pkm_mapk22_diff_1e-13_Fig4I replicate Figure 4I.

DAG acting as a Molecule in  Ajay_Bhalla_2007_ReacDiff1_1e-13 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics Pathway No. : 533	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[1] Pathway No. : 539	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[2] Pathway No. : 545	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[3] Pathway No. : 551	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[4] Pathway No. : 557	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[5] Pathway No. : 563	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[6] Pathway No. : 567	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[7] Pathway No. : 575	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[8] Pathway No. : 581	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[9] Pathway No. : 587	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[10] Pathway No. : 593	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[11] Pathway No. : 599	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[12] Pathway No. : 605	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[13] Pathway No. : 611	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[14] Pathway No. : 617	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[15] Pathway No. : 623	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[16] Pathway No. : 629	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[17] Pathway No. : 635	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[18] Pathway No. : 641	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[19] Pathway No. : 647	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[20] Pathway No. : 653	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[21] Pathway No. : 659	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[22] Pathway No. : 665	12.2	1.5	Yes
DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[23] Pathway No. : 671	12.2	1.5	Yes

DAG acting as a Substrate in a reaction in  Ajay_Bhalla_2007_ReacDiff1_1e-13 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 527	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
2	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 527	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
3	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 534	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
4	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 534	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
5	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 552	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
6	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 540	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
7	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 540	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
8	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 546	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
9	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 546	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
10	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 576	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
11	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 552	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
12	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 558	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
13	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 558	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
14	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 564	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
15	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 564	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
16	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 570	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
17	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 570	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
18	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 624	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
19	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 624	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
20	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 576	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
21	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 582	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
22	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 582	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
23	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 588	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
24	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 588	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
25	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 594	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
26	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 594	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
27	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 600	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
28	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 600	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
29	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 606	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
30	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 606	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
31	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 612	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
32	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 612	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
33	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 618	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
34	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 618	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
35	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 630	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
36	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 630	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
37	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 636	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
38	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 636	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
39	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 642	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
40	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 642	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
41	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 648	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
42	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 648	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
43	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 654	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
44	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 654	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
45	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 660	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
46	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 660	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
47	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 666	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
48	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 666	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
49	PKC-act-by-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 672	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
50	PKC-n-DAG	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	PKC Pathway No. : 672	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9