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Molecule Parameter List for PIP3_PDK1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

PIP3_PDK1 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AKT	87	Network	Shared_Object_AKT,  AKT_mod
This is one of the sub-model of BDNF signaling cascade. PIP3 activies AKT, leading to accumulation of Rheb-GTP, a regulator of mTOR.

PIP3_PDK1 acting as a Molecule in  AKT Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PIP3_PDK1	AKT Accession No. : 87	AKT_mod Pathway No. : 1086	0	999.97	No

PIP3_PDK1 acting as an Enzyme in  AKT Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PIP3_PDK1 / phospho_thr308	AKT Accession No. : 87	AKT_mod Pathway No. : 1086	0.399987	10	4	explicit E-S complex	Substrate PIP3_AKT Product PIP3_AKT_thr308

PIP3_PDK1 acting as a Product in a reaction in  AKT Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
PIP3_bind_PDK1	AKT Accession No. : 87	AKT_mod Pathway No. : 1086	0.7 (uM^-1 s^-1)	0.98 (s^-1)	Kd(bf) = 1.4(uM)	-	Substrate PDK1 PIP3 Product PIP3_PDK1