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Molecule Parameter List for PIP3 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| PIP3 participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 2 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | AKT | 87 | Network |
Shared_Object_AKT, AKT_mod | | This is one of the sub-model of BDNF signaling cascade. PIP3 activies AKT, leading to accumulation of Rheb-GTP, a regulator of mTOR. |
PIP3 acting as a Molecule in AKT Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | PIP3 | AKT
Accession No. : 87 | Shared_Object_
AKT
Pathway No. : 1085 | 0 | 999.97 | No |
PIP3 acting as a Substrate in a reaction in AKT Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | PIP3_bind_AKT | AKT
Accession No. : 87 | AKT_mod
Pathway No. : 1086 | 45.0003
(uM^-1 s^-1) | 0.089
(s^-1) | Kd(bf) = 0.002(uM) | - | Substrate
AKT
PIP3
Product
PIP3_AKT
| | 2 | PIP3_bind_PDK1 | AKT
Accession No. : 87 | AKT_mod
Pathway No. : 1086 | 0.7
(uM^-1 s^-1) | 0.98
(s^-1) | Kd(bf) = 1.4(uM) | - | Substrate
PDK1
PIP3
Product
PIP3_PDK1
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| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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