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Molecule Parameter List for TSC1-TSC2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TSC1-TSC2 participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 1 | 1 | 0 | 0 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| AKT | 87 | Network | Shared_Object_AKT, AKT_mod |
| This is one of the sub-model of BDNF signaling cascade. PIP3 activies AKT, leading to accumulation of Rheb-GTP, a regulator of mTOR. | |||
TSC1-TSC2 acting as a Molecule in AKT Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered |
| TSC1-TSC2 | AKT Accession No. : 87 | AKT Pathway No. : 1085 | 1 | 999.97 | No |
TSC1-TSC2 acting as an Enzyme in AKT Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| TSC1-TSC2 / TSC2phospho | AKT Accession No. : 87 | AKT Pathway No. : 1085 | 0.299998 | 20 | 4 | explicit E-S complex | Substrate Rheb-GTP Product Rheb-GDP |
TSC1-TSC2 acting as a Substrate for an Enzyme in AKT Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
s473 / TSC2_phospho | AKT Accession No. : 87 | AKT_mod Pathway No. : 1086 | 10.2999 | 6 | 4 | explicit E-S complex | Substrate TSC1-TSC2 Product TSC1-TSC2* |
TSC1-TSC2 acting as a Product in a reaction in AKT Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
dephospho | AKT Accession No. : 87 | AKT_mod Pathway No. : 1086 | 0.01 (s^-1) | 0 (s^-1) | - | - | Substrate TSC1-TSC2* Product TSC1-TSC2 |