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Molecule Parameter List for TSC1-TSC2 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | AKT | 87 | Network |
Shared_Object_AKT, AKT_mod | | This is one of the sub-model of BDNF signaling cascade. PIP3 activies AKT, leading to accumulation of Rheb-GTP, a regulator of mTOR. |
TSC1-TSC2 acting as a Molecule in AKT Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | TSC1-TSC2 | AKT
Accession No. : 87 | Shared_Object_
AKT
Pathway No. : 1085 | 1 | 999.97 | No |
TSC1-TSC2 acting as an Enzyme in AKT Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | TSC1-TSC2 /
TSC2phospho
| AKT
Accession No. : 87 | Shared_Object_
AKT
Pathway No. : 1085 | 0.299998 | 20 | 4 | explicit E-S complex | Substrate
Rheb-GTP
Product
Rheb-GDP
|
TSC1-TSC2 acting as a Substrate for an Enzyme in AKT Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PIP3_AKT-t308_
s473 /
TSC2_phospho | AKT
Accession No. : 87 | AKT_mod
Pathway No. : 1086 | 10.2999 | 6 | 4 | explicit E-S complex | Substrate
TSC1-TSC2
Product
TSC1-TSC2*
|
TSC1-TSC2 acting as a Product in a reaction in AKT Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | TSC1-2_
dephospho | AKT
Accession No. : 87 | AKT_mod
Pathway No. : 1086 | 0.01
(s^-1) | 0
(s^-1) | - | - | Substrate
TSC1-TSC2*
Product
TSC1-TSC2
|
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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