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Molecule Parameter List for eIF4E

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

eIF4E participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	2	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
4EBP	89	Network	Shared_Object_4EBP,  mTOR_model,  4E-BP_mod
Rheb-GTP activates mTOR, again with regulation by MAPK, leading to formation of the eIF4F-mRNA complex.

eIF4E acting as a Molecule in  4EBP Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
eIF4E	4EBP Accession No. : 89	Shared_Object_ 4EBP Pathway No. : 1090	0	1000	No

eIF4E acting as a Substrate in a reaction in  4EBP Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	eIF4E_bind_BP2	4EBP Accession No. : 89	4E-BP_mod Pathway No. : 1092	49.999 (uM^-1 s^-1)	0.15 (s^-1)	Kd(bf) = 0.003(uM)	-	Substrate 4E-BP eIF4E Product eIF4E-BP
2	eIF4F_clx	4EBP Accession No. : 89	Shared_Object_ 4EBP Pathway No. : 1090	30.0001 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0033(uM)	-	Substrate eIF4E eIF4G-A_clx Product eIF4F

eIF4E acting as a Product in a reaction in  4EBP Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	eIF4E-BP2_disso	4EBP Accession No. : 89	4E-BP_mod Pathway No. : 1092	4 (s^-1)	1 (uM^-1 s^-1)	Kd(cb) = 0.25(uM)	-	Substrate eIF4E_4E-BP_ t37_46_s65 Product 4E-BP_thr37_46_ s65 eIF4E
2	eIF4E-BP_disso	4EBP Accession No. : 89	Shared_Object_ 4EBP Pathway No. : 1090	1 (s^-1)	0.1 (uM^-1 s^-1)	Kd(cb) = 0.1(uM)	-	Substrate eIF4E-BP_thr37_ 46 Product 4E-BP_t37_46 eIF4E