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Molecule Parameter List for eIF4E

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
eIF4E participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000022

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
4EBP89Network
Shared_Object_4EBP,  mTOR_model,  4E-BP_mod 
Rheb-GTP activates mTOR, again with regulation by MAPK, leading to formation of the eIF4F-mRNA complex.

eIF4E acting as a Molecule in  4EBP Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
eIF4E4EBP
Accession No. : 89
  • Shared_Object_
    4EBP
    Pathway No. : 1090
    		• 01000No

    eIF4E acting as a Substrate in a reaction in      4EBP Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1eIF4E_bind_BP24EBP
    Accession No. : 89    		4E-BP_mod
    Pathway No. : 1092    		49.999
    (uM^-1 s^-1)    		0.15
    (s^-1)    		Kd(bf) = 0.003(uM)-Substrate
    4E-BP
    eIF4E

    Product
    eIF4E-BP
    2eIF4F_clx4EBP
    Accession No. : 89
  • Shared_Object_
    4EBP
    Pathway No. : 1090
    		• 30.0001
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0033(uM)-Substrate
    eIF4E
    eIF4G-A_clx

    Product
    eIF4F

    eIF4E acting as a Product in a reaction in      4EBP Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1eIF4E-BP2_disso4EBP
    Accession No. : 89    		4E-BP_mod
    Pathway No. : 1092    		4
    (s^-1)    		1
    (uM^-1 s^-1)    		Kd(cb) = 0.25(uM)-Substrate
  • eIF4E_4E-BP_
    t37_46_s65

    Product
  • 4E-BP_thr37_46_
    s65
    eIF4E
    • 2eIF4E-BP_disso4EBP
    Accession No. : 89
  • Shared_Object_
    4EBP
    Pathway No. : 1090
    		• 1
    (s^-1)    		0.1
    (uM^-1 s^-1)    		Kd(cb) = 0.1(uM)-Substrate
  • eIF4E-BP_thr37_
    46

    Product
    4E-BP_t37_46
    eIF4E


    • Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.