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Name Notes Model

Molecule Parameter List for PIP3

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

PIP3 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	3	2	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
mTOR_pathway	92	Network	Shared_Object_mTOR_pathway,  AKT_mod,  S6Kinase,   PI3K_mod,  TrKB_mod,  mTOR_model,   MAPK,  PKC,  4E-BP_mod,   Ras,  Sos,  43S_complex,   CaM
This model consists of various sub-modules. They are as follows: 1) BDNF receptor signaling 2) AKT signaling 3) 4E-BP model 4) S6 Kinase model 5) CaMKIII model 6) Protein synthesis model 7) CaM 8) PKC 9) MAPK model.

PIP3 acting as a Molecule in  mTOR_pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PIP3	mTOR_pathway Accession No. : 92	Shared_Object_ mTOR_pathway Pathway No. : 1097	0	1000	No

PIP3 acting as a Substrate for an Enzyme in  mTOR_pathway Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PTEN  / PIP3_dephosp	mTOR_pathway Accession No. : 92	Shared_Object_ mTOR_pathway Pathway No. : 1097	0.0799995	5.5	4	explicit E-S complex	Substrate PIP3 Product PIP2

PIP3 acting as a Product of an Enzyme in  mTOR_pathway Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	Shc_star_ Grb2-Gab1_PI3K_ clx  / Phospho	mTOR_pathway Accession No. : 92	TrKB_mod Pathway No. : 1101	4.00001	4	4	explicit E-S complex	Substrate PIP2 Product PIP3
2	PI3K_basal  / basal_phosp	mTOR_pathway Accession No. : 92	PI3K_mod Pathway No. : 1100	4.00002	4	4	explicit E-S complex	Substrate PIP2 Product PIP3
3	Ras-GTP_PI3K  / PIP2_phospho_ Ras-GTP	mTOR_pathway Accession No. : 92	Shared_Object_ mTOR_pathway Pathway No. : 1097	4.00002	4	4	explicit E-S complex	Substrate PIP2 Product PIP3

PIP3 acting as a Substrate in a reaction in  mTOR_pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	PIP3_bind_AKT	mTOR_pathway Accession No. : 92	AKT_mod Pathway No. : 1098	45.0003 (uM^-1 s^-1)	0.089 (s^-1)	Kd(bf) = 0.002(uM)	-	Substrate AKT PIP3 Product PIP3_AKT
2	PIP3_bind_PDK1	mTOR_pathway Accession No. : 92	AKT_mod Pathway No. : 1098	0.7 (uM^-1 s^-1)	0.98 (s^-1)	Kd(bf) = 1.4(uM)	-	Substrate PDK1 PIP3 Product PIP3_PDK1