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Molecule Parameter List for PIP3_AKT | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PIP3_AKT participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 1 | 1 | 0 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| mTOR_pathway | 92 | Network | Shared_Object_mTOR_pathway, AKT_mod, S6Kinase, PI3K_mod, TrKB_mod, mTOR_model, MAPK, PKC, 4E-BP_mod, Ras, Sos, 43S_complex, CaM |
| This model consists of various sub-modules. They are as follows: 1) BDNF receptor signaling 2) AKT signaling 3) 4E-BP model 4) S6 Kinase model 5) CaMKIII model 6) Protein synthesis model 7) CaM 8) PKC 9) MAPK model. | |||
PIP3_AKT acting as a Molecule in mTOR_pathway Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered |
| PIP3_AKT | mTOR_pathway Accession No. : 92 | AKT_mod Pathway No. : 1098 | 0 | 1000 | No |
PIP3_AKT acting as a Substrate for an Enzyme in mTOR_pathway Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| PIP3_PDK1 / phospho_thr308 | mTOR_pathway Accession No. : 92 | AKT_mod Pathway No. : 1098 | 0.399987 | 10 | 4 | explicit E-S complex | Substrate PIP3_AKT Product PIP3_AKT_thr308 |
PIP3_AKT acting as a Product of an Enzyme in mTOR_pathway Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| PP2A / AKTthr308 | mTOR_pathway Accession No. : 92 | mTOR_pathway Pathway No. : 1097 | 4.80015 | 1.8 | 4 | explicit E-S complex | Substrate PIP3_AKT_thr308 Product PIP3_AKT |
PIP3_AKT acting as a Product in a reaction in mTOR_pathway Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| PIP3_bind_AKT | mTOR_pathway Accession No. : 92 | AKT_mod Pathway No. : 1098 | 45.0003 (uM^-1 s^-1) | 0.089 (s^-1) | Kd(bf) = 0.002(uM) | - | Substrate AKT PIP3 Product PIP3_AKT |