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Molecule Parameter List for PI3K | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PI3K participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 0 | 3 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| mTOR_pathway | 92 | Network | Shared_Object_mTOR_pathway, AKT_mod, S6Kinase, PI3K_mod, TrKB_mod, mTOR_model, MAPK, PKC, 4E-BP_mod, Ras, Sos, 43S_complex, CaM |
| This model consists of various sub-modules. They are as follows: 1) BDNF receptor signaling 2) AKT signaling 3) 4E-BP model 4) S6 Kinase model 5) CaMKIII model 6) Protein synthesis model 7) CaM 8) PKC 9) MAPK model. | |||
PI3K acting as a Molecule in mTOR_pathway Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered |
| PI3K | mTOR_pathway Accession No. : 92 | PI3K_mod Pathway No. : 1100 | 0.1 | 1000 | No |
PI3K acting as a Substrate in a reaction in mTOR_pathway Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | |
| 1 | PI3K_act | mTOR_pathway Accession No. : 92 | PI3K_mod Pathway No. : 1100 | 5.0002 (uM^-1 s^-1) | 0.08 (s^-1) | Kd(bf) = 0.016(uM) | - | Substrate PI3K Grb2-Gab1_clx Product Grb2-Gab1_PI3K_ clx |
| 2 | basal_PI3K_act | mTOR_pathway Accession No. : 92 | PI3K_mod Pathway No. : 1100 | 0.0007 (s^-1) | 0.45 (s^-1) | Keq = 661.7647(uM) | 2.219sec | Substrate PI3K Product PI3K_basal |
| 3 | Ras-GTP | mTOR_pathway Accession No. : 92 | mTOR_pathway Pathway No. : 1097 | 1.7999 (uM^-1 s^-1) | 5 (s^-1) | Kd(bf) = 2.7779(uM) | - | Substrate GTP-Ras PI3K Product Ras-GTP_PI3K |