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Molecule Parameter List for eIF4E-BP_thr37_46

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

eIF4E-BP_thr37_46 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	2	2	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
mTOR_pathway	92	Network	Shared_Object_mTOR_pathway,  AKT_mod,  S6Kinase,   PI3K_mod,  TrKB_mod,  mTOR_model,   MAPK,  PKC,  4E-BP_mod,   Ras,  Sos,  43S_complex,   CaM
This model consists of various sub-modules. They are as follows: 1) BDNF receptor signaling 2) AKT signaling 3) 4E-BP model 4) S6 Kinase model 5) CaMKIII model 6) Protein synthesis model 7) CaM 8) PKC 9) MAPK model.

eIF4E-BP_thr37_46 acting as a Molecule in  mTOR_pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
eIF4E-BP_thr37_46	mTOR_pathway Accession No. : 92	4E-BP_mod Pathway No. : 1105	0	1000	No

eIF4E-BP_thr37_46 acting as a Substrate for an Enzyme in  mTOR_pathway Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP2A  / PP2A_4EBP	mTOR_pathway Accession No. : 92	Shared_Object_ mTOR_pathway Pathway No. : 1097	8.80028	1	4	explicit E-S complex	Substrate eIF4E-BP_thr37_ 46 Product eIF4E-BP
2	MAPK_star  / MAPK_4E-BP_ phospho	mTOR_pathway Accession No. : 92	Shared_Object_ mTOR_pathway Pathway No. : 1097	17.9	0.16	4	explicit E-S complex	Substrate eIF4E-BP_thr37_ 46 Product eIF4E_4E-BP_ t37_46_s65

eIF4E-BP_thr37_46 acting as a Product of an Enzyme in  mTOR_pathway Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP2A  / PP2A_4E-BP	mTOR_pathway Accession No. : 92	Shared_Object_ mTOR_pathway Pathway No. : 1097	8.80028	1	4	explicit E-S complex	Substrate eIF4E_4E-BP_ t37_46_s65 Product eIF4E-BP_thr37_ 46
2	TOR_Rheb-GTP_ clx  / TOR_4E-BP_ phospho	mTOR_pathway Accession No. : 92	Shared_Object_ mTOR_pathway Pathway No. : 1097	1.80001	1	4	explicit E-S complex	Substrate eIF4E-BP Product eIF4E-BP_thr37_ 46

eIF4E-BP_thr37_46 acting as a Substrate in a reaction in  mTOR_pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
eIF4E-BP_disso	mTOR_pathway Accession No. : 92	Shared_Object_ mTOR_pathway Pathway No. : 1097	1 (s^-1)	0.1 (uM^-1 s^-1)	Kd(cb) = 0.1(uM)	-	Substrate eIF4E-BP_thr37_ 46 Product 4E-BP_t37_46 eIF4E