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Molecule Parameter List for Shc_star

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

Shc_star participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	1	3	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
mTOR_pathway	92	Network	Shared_Object_mTOR_pathway,  AKT_mod,  S6Kinase,   PI3K_mod,  TrKB_mod,  mTOR_model,   MAPK,  PKC,  4E-BP_mod,   Ras,  Sos,  43S_complex,   CaM
This model consists of various sub-modules. They are as follows: 1) BDNF receptor signaling 2) AKT signaling 3) 4E-BP model 4) S6 Kinase model 5) CaMKIII model 6) Protein synthesis model 7) CaM 8) PKC 9) MAPK model.

Shc_star acting as a Molecule in  mTOR_pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Shc_star	mTOR_pathway Accession No. : 92	Shared_Object_ mTOR_pathway Pathway No. : 1097	0	1000	No

Shc_star acting as a Product of an Enzyme in  mTOR_pathway Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
BDNF_TrkB2_ star_clx  / Shc_phospho	mTOR_pathway Accession No. : 92	TrKB_mod Pathway No. : 1101	0.833306	0.3	4	explicit E-S complex	Substrate Shc Product Shc_star

Shc_star acting as a Substrate in a reaction in  mTOR_pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	Shc_star_ dephospho	mTOR_pathway Accession No. : 92	PI3K_mod Pathway No. : 1100	0.2 (s^-1)	0 (s^-1)	-	-	Substrate Shc_star Product Shc
2	Grb2_bind_Shc	mTOR_pathway Accession No. : 92	PI3K_mod Pathway No. : 1100	1 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 1(uM)	-	Substrate Grb2 Shc_star Product Shc_star_Grb2_ clx
3	Shc_bind_ Sos.Grb2	mTOR_pathway Accession No. : 92	Sos Pathway No. : 1107	0.5 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.2(uM)	-	Substrate Shc_star Sos.Grb2 Product Shc_ star.Sos.Grb2
	Sasaoka et al JBC 269:51 pp 32621 1994, table on pg 32623 indicates that this pathway accounts for about 50% of the GEF activation. (88% - 39%). Error is large, about 20%. Fig 1 is most useful in constraining rates. Chook et al JBC 271:48 pp 30472, 1996 say that the Kd is 0.2 uM for Shc binding to EGFR. The Kd for Grb direct binding is 0.7, so we'll ignore it.