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Name Notes Model

Molecule Parameter List for 43Scomplex

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

43Scomplex participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
mTOR_pathway	92	Network	Shared_Object_mTOR_pathway,  AKT_mod,  S6Kinase,   PI3K_mod,  TrKB_mod,  mTOR_model,   MAPK,  PKC,  4E-BP_mod,   Ras,  Sos,  43S_complex,   CaM
This model consists of various sub-modules. They are as follows: 1) BDNF receptor signaling 2) AKT signaling 3) 4E-BP model 4) S6 Kinase model 5) CaMKIII model 6) Protein synthesis model 7) CaM 8) PKC 9) MAPK model.

43Scomplex acting as a Molecule in  mTOR_pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
43Scomplex	mTOR_pathway Accession No. : 92	Shared_Object_ mTOR_pathway Pathway No. : 1097	0	1000	No
40S_complex consist of Quaternary complex, mRNA complex, 40S Ribosomes.

43Scomplex acting as a Substrate in a reaction in  mTOR_pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
activation	mTOR_pathway Accession No. : 92	Shared_Object_ mTOR_pathway Pathway No. : 1097	1 (uM^-1 s^-1)	0.9 (s^-1)	Kd(bf) = 0.9(uM)	-	Substrate 43Scomplex 60S_R Product 80S_ribos_clx

43Scomplex acting as a Product in a reaction in  mTOR_pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	QR_binds_M	mTOR_pathway Accession No. : 92	43S_complex Pathway No. : 1108	0.49 (uM^-1 s^-1)	0.0045 (s^-1)	Kd(bf) = 0.0092(uM)	-	Substrate Q.R eIF4F-mRNA_clx Product 43Scomplex
2	RM_binds_Q	mTOR_pathway Accession No. : 92	43S_complex Pathway No. : 1108	0.098 (uM^-1 s^-1)	0.0017 (s^-1)	Kd(bf) = 0.0172(uM)	-	Substrate Quaternary_clx RM Product 43Scomplex