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Molecule Parameter List for PKC_dash_active

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*PKC_dash_active* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	4	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
mRNA synthesis	94	Network	kinetics, compartment_1, compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

PKC_dash_active acting as a Molecule in mRNA synthesis Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PKC_dash_active	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	0.01	1000	Yes

PKC_dash_active acting as an Enzyme in mRNA synthesis Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PKC_dash_active / phosph_dash_AC2	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	33.3333	4	4	explicit E-S complex	Substrate AC2 Product AC2_star

2	PKC_dash_active / PKC_dash_inact_ dash_GAP	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	3.3333	4	4	explicit E-S complex	Substrate GAP Product GAP_star
	Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
3	PKC_dash_active / PKC_dash_act_ dash_GEF	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	3.3333	4	4	explicit E-S complex	Substrate inact_dash_GEF Product GEF_star
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
4	PKC_dash_active / PKC_dash_act_ dash_raf	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	66.668	4	4	explicit E-S complex	Substrate craf_dash_1 Product craf_dash_1_ star

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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