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Molecule Parameter List for cAMP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*cAMP* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	4	6	4	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
mRNA synthesis	94	Network	kinetics, compartment_1, compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

cAMP acting as a Molecule in mRNA synthesis Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
cAMP	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	0	1000	No

cAMP acting as a Substrate for an Enzyme in mRNA synthesis Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	cAMP_dash_PDE / PDE	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	19.8413	10	4	explicit E-S complex	Substrate cAMP Product cAMP

2	PDE1 / PDE1	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	39.7	1.667	4.00119976005	explicit E-S complex	Substrate cAMP Product cAMP

3	CaM.PDE1 / CaM.PDE1	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	39.6825	10	4	explicit E-S complex	Substrate cAMP Product cAMP

4	cAMP_dash_PDE_ star / PDE_p	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	19.8413	20	4	explicit E-S complex	Substrate cAMP Product cAMP

cAMP acting as a Product of an Enzyme in mRNA synthesis Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	AC1_dash_CaM / kenz	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	20	18	4	explicit E-S complex	Substrate ATP Product cAMP

2	cAMP_dash_PDE / PDE	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	19.8413	10	4	explicit E-S complex	Substrate cAMP Product cAMP

3	PDE1 / PDE1	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	39.7	1.667	4.00119976005	explicit E-S complex	Substrate cAMP Product cAMP

4	CaM.PDE1 / CaM.PDE1	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	39.6825	10	4	explicit E-S complex	Substrate cAMP Product cAMP

5	AC2_star / kenz	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	20.1149	7	4	explicit E-S complex	Substrate ATP Product cAMP

6	cAMP_dash_PDE_ star / PDE_p	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	19.8413	20	4	explicit E-S complex	Substrate cAMP Product cAMP

cAMP acting as a Substrate in a reaction in mRNA synthesis Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	cAMP_dash_bind_ dash_site_dash_ B1	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	54 (uM^-1 s^-1)	33 (s^-1)	Kd(bf) = 0.6111(uM)	-	Substrate R2C2 cAMP Product R2C2_dash_cAMP

2	cAMP_dash_bind_ dash_site_dash_ B2	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	54 (uM^-1 s^-1)	33 (s^-1)	Kd(bf) = 0.6111(uM)	-	Substrate R2C2_dash_cAMP cAMP Product R2C2_dash_cAMP2

3	cAMP_dash_bind_ dash_site_dash_ A1	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	75 (uM^-1 s^-1)	110 (s^-1)	Kd(bf) = 1.4667(uM)	-	Substrate R2C2_dash_cAMP2 cAMP Product R2C2_dash_cAMP3

4	cAMP_dash_bind_ dash_site_dash_ A2	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	75 (uM^-1 s^-1)	32.5 (s^-1)	Kd(bf) = 0.4333(uM)	-	Substrate R2C2_dash_cAMP3 cAMP Product R2C2_dash_cAMP4

cAMP acting as a Product in a reaction in mRNA synthesis Network

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
dissociation	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	0.0005 (s^-1)	0.0001 (uM^-1 s^-1)	Kd(cb) = 0.2(uM)	-	Substrate R2_dash_cAMP4 Product R2 cAMP

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