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Molecule Parameter List for cAMP_dash_PDE

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*cAMP_dash_PDE* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	1	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
mRNA synthesis	94	Network	kinetics, compartment_1, compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

cAMP_dash_PDE acting as a Molecule in mRNA synthesis Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
cAMP_dash_PDE	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	0.45	1000	No

cAMP_dash_PDE acting as an Enzyme in mRNA synthesis Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
cAMP_dash_PDE / PDE	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	19.8413	10	4	explicit E-S complex	Substrate cAMP Product cAMP

cAMP_dash_PDE acting as a Substrate for an Enzyme in mRNA synthesis Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PKA_dash_active / phosph_dash_PDE	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	7.5	9	4	explicit E-S complex	Substrate cAMP_dash_PDE Product cAMP_dash_PDE_ star

cAMP_dash_PDE acting as a Product in a reaction in mRNA synthesis Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
dephosph_dash_ PDE	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	0.1 (s^-1)	0 (s^-1)	-	-	Substrate cAMP_dash_PDE_ star Product cAMP_dash_PDE

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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