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Name Notes Model

Molecule Parameter List for Rap1GAP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

Rap1GAP participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	2	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
mRNA synthesis	94	Network	kinetics,  compartment_1,  compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

Rap1GAP acting as a Molecule in  mRNA synthesis Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Rap1GAP	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	0.012	1000	No

Rap1GAP acting as an Enzyme in  mRNA synthesis Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	Rap1GAP / RapGAP2	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	1	2	100	explicit E-S complex	Substrate bRaf_Rap1GTP Product Rap1GDP bRaf
2	Rap1GAP / RapGAP1	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	1	2	100	explicit E-S complex	Substrate Rap1GTP Product Rap1GDP