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Molecule Parameter List for Grb2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Grb2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000020

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
mRNA synthesis94Network
kinetics,  compartment_1,  compartment_2 
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

Grb2 acting as a Molecule in  mRNA synthesis Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
Grb2mRNA synthesis
Accession No. : 94		kinetics
Pathway No. : 1112		11000No
There is probably a lot of it in the cell: it is also known as Ash (abundant src homology protein I think). Also Waters et al JBC 271:30 18224 1996 say that only a small fraction of cellular Grb is precipitated out when SoS is precipitated. As most of the Sos seems to be associated with Grb2, it would seem like there is a lot of the latter. Say 1 uM. I haven't been able to find a decent....

Grb2 acting as a Substrate in a reaction in  mRNA synthesis Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
 NameAccession NamePathway NameKfKbKdtauReagents
1Grb2_bind_SosmRNA synthesis
Accession No. : 94		kinetics
Pathway No. : 1112		0.25
(uM^-1 s^-1)		0.0168
(s^-1)		Kd(bf) = 0.0672(uM)-Substrate
Grb2
Sos

Product
Sos.Grb2
 
2
  • Grb2_bind_Sos_
    star
    		• mRNA synthesis
    Accession No. : 94    		kinetics
    Pathway No. : 1112    		0.025
    (uM^-1 s^-1)    		0.0168
    (s^-1)    		Kd(bf) = 0.672(uM)-Substrate
    Grb2
    Sos_star

    Product
    Sos_star.Grb2
     


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