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Name Notes Model

Molecule Parameter List for MAPK_star

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

MAPK_star participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	3	1	1	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
mRNA synthesis	94	Network	kinetics,  compartment_1,  compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

MAPK_star acting as a Molecule in  mRNA synthesis Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
MAPK_star	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	0	1000	No

MAPK_star acting as a Summed Molecule in  mRNA synthesis Network

Accession Name	Pathway Name	Target	Input
mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	MAPK_active_total	MAPK_star Basal_MAPK_ active Basal_MAPK_ active

MAPK_star acting as an Enzyme in  mRNA synthesis Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	MAPK_star / phosph_Sos	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	2.56	10	4	explicit E-S complex	Substrate Sos Product Sos_star
2	MAPK_star / phospho_S6K	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	5.2999	1.7	4	explicit E-S complex	Substrate RSK Product pRSK
3	MAPK_star / MAPK_star_dash_ feedback	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	25.641	10	4	explicit E-S complex	Substrate craf_dash_1_ star Product craf_dash_1_ star_star
	Ueki et al JBC 269(22):15756-15761 show the presence of this step, but not the rate consts, which are derived from Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the MAPK* notes.

MAPK_star acting as a Substrate for an Enzyme in  mRNA synthesis Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
MKP_dash_1  / MKP1_dash_thr_ dash_deph	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	0.1333	4	4	explicit E-S complex	Substrate MAPK_star Product MAPK_dash_tyr
See MKP1-tyr-deph

MAPK_star acting as a Product of an Enzyme in  mRNA synthesis Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
MAPKK_star  / MAPKKthr	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	0.0463	0.3	4	explicit E-S complex	Substrate MAPK_dash_tyr Product MAPK_star
Rate consts same as for MAPKKtyr.

MAPK_star acting as a Substrate in a reaction in  mRNA synthesis Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
transport_MAPK	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	0.0001 (s^-1)	0.0011 (s^-1)	Keq = 11.1(uM)	833.333sec	Substrate MAPK_star Product MAPK_star

MAPK_star acting as a Product in a reaction in  mRNA synthesis Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
transport_MAPK	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	0.0001 (s^-1)	0.0011 (s^-1)	Keq = 11.1(uM)	833.333sec	Substrate MAPK_star Product MAPK_star