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Molecule Parameter List for MAPK_star | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | mRNA synthesis | 94 | Network |
kinetics, compartment_1, compartment_2 | | The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway. |
MAPK_star acting as a Molecule in mRNA synthesis Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | MAPK_star | mRNA synthesis
Accession No. : 94 | kinetics
Pathway No. : 1112 | 0 | 1000 | No | | |
MAPK_star acting as a Summed Molecule in mRNA synthesis Network
MAPK_star acting as an Enzyme in mRNA synthesis Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | MAPK_star /
phosph_Sos
| mRNA synthesis
Accession No. : 94 | kinetics
Pathway No. : 1112 | 2.56 | 10 | 4 | explicit E-S complex | Substrate
Sos
Product
Sos_star
| | | | | 2 | MAPK_star /
phospho_S6K
| mRNA synthesis
Accession No. : 94 | kinetics
Pathway No. : 1112 | 5.2999 | 1.7 | 4 | explicit E-S complex | Substrate
RSK
Product
pRSK
| | | | | 3 | MAPK_star /
MAPK_star_dash_
feedback
| mRNA synthesis
Accession No. : 94 | kinetics
Pathway No. : 1112 | 25.641 | 10 | 4 | explicit E-S complex | Substrate
craf_dash_1_
star
Product
craf_dash_1_
star_star
| | | Ueki et al JBC 269(22):15756-15761 show the presence of this step, but not the rate consts, which are derived from Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the MAPK* notes. |
MAPK_star acting as a Substrate for an Enzyme in mRNA synthesis Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | MKP_dash_1 /
MKP1_dash_thr_
dash_deph
| mRNA synthesis
Accession No. : 94 | kinetics
Pathway No. : 1112 | 0.1333 | 4 | 4 | explicit E-S complex | Substrate
MAPK_star
Product
MAPK_dash_tyr
| | See MKP1-tyr-deph |
MAPK_star acting as a Product of an Enzyme in mRNA synthesis Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | MAPKK_star /
MAPKKthr | mRNA synthesis
Accession No. : 94 | kinetics
Pathway No. : 1112 | 0.0463 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK_dash_tyr
Product
MAPK_star
| | Rate consts same as for MAPKKtyr. |
MAPK_star acting as a Substrate in a reaction in mRNA synthesis Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | transport_MAPK | mRNA synthesis
Accession No. : 94 | kinetics
Pathway No. : 1112 | 0.0001
(s^-1) | 0.0011
(s^-1) | Keq = 11.1(uM) | 833.333sec | Substrate
MAPK_star
Product
MAPK_star
| | |
MAPK_star acting as a Product in a reaction in mRNA synthesis Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | transport_MAPK | mRNA synthesis
Accession No. : 94 | kinetics
Pathway No. : 1112 | 0.0001
(s^-1) | 0.0011
(s^-1) | Keq = 11.1(uM) | 833.333sec | Substrate
MAPK_star
Product
MAPK_star
| | |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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