DOQCS database

NCBS Home page

Accession List

Pathway List

Authorized Users

Help

News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

Molecule Parameter List for Rap1GTP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*Rap1GTP* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	1	2	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Differential syn thesis of mRNA	95	Network	kinetics, compartment_1, compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

Rap1GTP acting as a Molecule in Differential synthesis of mRNA Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Rap1GTP	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	0	1000	No

Rap1GTP acting as a Substrate for an Enzyme in Differential synthesis of mRNA Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
Rap1GAP / RapGAP1	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	1	2	100	explicit E-S complex	Substrate Rap1GTP Product Rap1GDP

Rap1GTP acting as a Product of an Enzyme in Differential synthesis of mRNA Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
CRK_C3G_Cbl_ star_clx / RAP_GEF	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	0.01	0.2	4	explicit E-S complex	Substrate Rap1GDP Product Rap1GTP

Rap1GTP acting as a Substrate in a reaction in Differential synthesis of mRNA Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	intrinsic_ GTPase	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	0.0001 (s^-1)	0 (s^-1)	-	-	Substrate Rap1GTP Product Rap1GDP

2	B_dash_Raf_ bind_Rap1GTP	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	60 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.0083(uM)	-	Substrate Rap1GTP bRaf Product bRaf_Rap1GTP

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.