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Molecule Parameter List for craf_dash_1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*craf_dash_1* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	1	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Differential syn thesis of mRNA	95	Network	kinetics, compartment_1, compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

craf_dash_1 acting as a Molecule in Differential synthesis of mRNA Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
craf_dash_1	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	0.2	1000	No

craf_dash_1 acting as a Substrate for an Enzyme in Differential synthesis of mRNA Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PKC_dash_active / PKC_dash_act_ dash_raf	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	66.668	4	4	explicit E-S complex	Substrate craf_dash_1 Product craf_dash_1_ star

craf_dash_1 acting as a Product of an Enzyme in Differential synthesis of mRNA Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PPhosphatase2A / craf_dash_deph	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	15.6568	6	4	explicit E-S complex	Substrate craf_dash_1_ star Product craf_dash_1
See parent PPhosphatase2A for parms

craf_dash_1 acting as a Substrate in a reaction in Differential synthesis of mRNA Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Ras_dash_act_ dash_unphosph_ dash_raf	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	6 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.1667(uM)	-	Substrate GTP_dash_Ras craf_dash_1 Product Raf_dash_GTP_ dash_Ras
18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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