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Molecule Parameter List for pRSK

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*pRSK* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	1	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Differential syn thesis of mRNA	95	Network	kinetics, compartment_1, compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

pRSK acting as a Molecule in Differential synthesis of mRNA Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
pRSK	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	0	1000	No

pRSK acting as a Substrate for an Enzyme in Differential synthesis of mRNA Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PP2A / dephos_S6K	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	8.8005	1	4	explicit E-S complex	Substrate pRSK Product RSK

pRSK acting as a Product of an Enzyme in Differential synthesis of mRNA Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
MAPK_star / phospho_S6K	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	5.2999	1.7	4	explicit E-S complex	Substrate RSK Product pRSK

pRSK acting as a Substrate in a reaction in Differential synthesis of mRNA Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
RSK_ autophosphorylat ion	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	0.1 (s^-1)	10 (s^-1)	Keq = 100(uM)	0.099sec	Substrate pRSK Product ppRSK

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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