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Molecule Parameter List for PP1_dash_I1_star

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*PP1_dash_I1_star* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	2	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Differential syn thesis of mRNA	95	Network	kinetics, compartment_1, compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

PP1_dash_I1_star acting as a Molecule in Differential synthesis of mRNA Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PP1_dash_I1_star	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	0	1000	No

PP1_dash_I1_star acting as a Substrate for an Enzyme in Differential synthesis of mRNA Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP2A / PP2A_dash_ dephosph_dash_ PP1_dash_I_star	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	7.8283	6	4.16666666667	explicit E-S complex	Substrate PP1_dash_I1_ star Product PP1_dash_I1
	k1 changed from 3.3e-6 to 6.6e-6
2	CaM_Ca_n_dash_ CaNAB / dephosph_dash_ PP1_dash_I_star	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	4.9708	0.34	4	explicit E-S complex	Substrate PP1_dash_I1_ star Product PP1_dash_I1

PP1_dash_I1_star acting as a Product in a reaction in Differential synthesis of mRNA Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Inact_dash_PP1	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	499.974 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0002(uM)	-	Substrate I1_star PP1_dash_ active_c Product PP1_dash_I1_ star
K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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