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Molecule List for pathway CaM (Pathway Number 81) in Accession Synaptic_Network (Accession Number 16) | Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.
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The entries are grouped according to Pathway Number and are alternately color coded using  and  color. |
| |
Name | Accession
Type | Initial
Conc.
(uM) | Volume
(fL) | Buffered | Sum Total Of | | 1 | CaM | Network | 20 | 0 | No | - | | | There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al, Mol Biol. of the Cell, Garland Publishers) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels. | | 2 | neurogranin | Network | 10 | 0 | No | - | | | Also known as RC3 and p17 and BICKS. Concentration in brain >> 2 uM from Martzen and Slemmon J Neurosci 64 92-100 1995. Concentration in dend spines is much higher than overall, so it could be anywhere from 2 uM to 50. We will estimate 10 uM as a starting point. Gerendasy et al JBC 269:35 22420-22426 1994 have a skeleton model (no numbers) indicating CaM-Ca(n) binding. | | 3 | neurogranin-CaM | Network | 0 | 0 | No | - | | | This is the CaM-bound form of neurogranin. This CaM is taken out of circulation and thus reduces the signaling through CaM. | | 4 | neurogranin* | Network | 0 | 0 | No | - | | | The phosphorylated form of neurogranin does not bind CaM (Huang et al ABB 305:2 570-580 1993) |
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