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Molecule List for pathway Sos (Pathway Number 337) in Accession Ajay_Bhalla_2004_PKM_MKP3_Tuning (Accession Number 77) | Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.
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The entries are grouped according to Pathway Number and are alternately color coded using  and  color. |
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Name | Accession
Type | Initial
Conc.
(uM) | Volume
(fL) | Buffered | Sum Total Of | | 1 | Sos.Grb2 | Network | 0 | 0 | No | - | | 2 | Sos*.Grb2 | Network | 0 | 0 | No | - | | 3 | Sos* | Network | 0 | 0 | No | - | | 4 | Sos | Network | 0.1 | 0 | No | - | | | I have tried using low (0.02 uM) initial concs, but these give a very flat response to EGF stim although the overall activation of Ras is not too bad. I am reverting to 0.1 because we expect a sharp initial response, followed by a decline. Sep 17 1997: The transient activation curve looks better with [Sos] = 0.05. Apr 26 1998: Some error there, it is better where it was at 0.1 | | 5 | Grb2 | Network | 1 | 0 | No | - | | | There is probably a lot of it in the cell: it is also known as Ash (abundant src homology protein I think). Also Waters et al JBC 271:30 18224 1996 say that only a small fraction of cellular Grb is precipitated out when SoS is precipitated. As most of the Sos seems to be associated with Grb2, it would seem like there is a lot of the latter. Say 1 uM. I haven't been able to find a decent.... |
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