| |
Name | Accession
Type | Initial
Conc.
(uM) | Volume
(fL) | Buffered | Sum Total Of |
| 1 | CaM | Network | 26.3333 | 0 | No | - |
| | There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels. |
| 2 | neurogranin-CaM | Network | 0 | 0 | No | - |
| 3 | neurogranin* | Network | 0 | 0 | No | - |
| | The phosph form does not bind CaM (Huang et al ABB 305:2 570-580 1993) |
| 4 | neurogranin | Network | 10 | 0 | No | - |
| | Also known as RC3 and p17 and BICKS. Conc in brain >> 2 uM from Martzen and Slemmon J neurosci 64 92-100 1995 but others say less without any #s. Conc in dend spines is much higher than overall, so it could be anywhere from 2 uM to 50. We will estimate 10 uM as a starting point. Gerendasy et al JBC 269:35 22420-22426 1994 have a skeleton model (no numbers) indicating CaM-Ca(n) binding .... |
| 5 | CaM-PSD | Network | 26.3333 | 0 | No | - |
| | There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels. |
| 6 |
neurogranin-CaM_
PSD | Network | 0 | 0 | No | - |
| 7 | neurogranin_PSD | Network | 10 | 0 | No | - |
| | Also known as RC3 and p17 and BICKS. Conc in brain >> 2 uM from Martzen and Slemmon J neurosci 64 92-100 1995 but others say less without any #s. Conc in dend spines is much higher than overall, so it could be anywhere from 2 uM to 50. We will estimate 10 uM as a starting point. Gerendasy et al JBC 269:35 22420-22426 1994 have a skeleton model (no numbers) indicating CaM-Ca(n) binding .... |
| 8 | neurogranin*_
PSD | Network | 0 | 0 | No | - |
| | The phosph form does not bind CaM (Huang et al ABB 305:2 570-580 1993) |
and 
color.